An adjuvanted whole cell vaccine as post-remission immunotherapy for acute leukemia

Leukemia cell-rhabdovirus vaccine: personalized immunotherapy for acute lymphoblastic leukemia.

PURPOSE Acute lymphoblastic leukemia (ALL) remains incurable in most adults. It has been difficult to provide effective immunotherapy to improve outcomes for the majority of patients. Rhabdoviruses induce strong antiviral immune responses. We hypothesized that mice administered ex vivo rhabdovirus-infected ALL cells [immunotherapy by leukemia-oncotropic virus (iLOV)] would develop robust antile...

Leukemia cell-rhabdovirus vaccine: personalized immunotherapy for acute lymphocytic leukemia

Cancer Therapy: Preclinical Leukemia Cell-Rhabdovirus Vaccine: Personalized Immunotherapy for Acute Lymphoblastic Leukemia

Purpose: Acute lymphoblastic leukemia (ALL) remains incurable in most adults. It has been difficult to provide effective immunotherapy to improve outcomes for the majority of patients. Rhabdoviruses induce strong antiviral immune responses. We hypothesized that mice administered ex vivo rhabdovirus-infected ALL cells [immunotherapy by leukemia-oncotropic virus (iLOV)] would develop robust antil...

Immunotherapy for acute leukemia

(allo-HCT) can be curative for patients with acute leukemia [1]. The anti-leukemia activity relies on the graft-versus-leukemia (GVL) effects that are elicited after allo-HCT, suggesting that anti-tumor immunity may be responsible for eradicating leukemia and preventing subsequent relapse. However, allo-HCT is associated with significant morbidity and mortality resulting from toxicity of dose-i...

In Vitro Cytotoxic Effects of Cuscuta chinensis Whole Extract on Human Acute Lymphoblastic Leukemia Cell Line

Background: One of the major paths for drug development is the study of bioactivities of natural products. Therefore, the aim of this study was to compare the cytotoxic effects of aqueous extract of whole Cuscuta chinensis Lam., which is a traditional medicinal herb commonly used in Iran and other oriental countries, on the human caucasian acute lymphoblastic leukemia (CCRF-CEM) and another hum...